The Powerpuff Girls is an American animated television series created by animator Craig McCracken for Cartoon Network. The show centers on Blossom, Bubbles, and Buttercup, three girls with superpowers, as well as their father, the brainy scientist Professor Utonium, who all live in the fictional city of Townsville, USA. The girls are frequently called upon by the town's childlike and naive mayor to help fight nearby criminals using their powers.
McCracken originally developed the show in 1992 as a cartoon short entitled Whoopass Stew! while in his second year at CalArts. Following a name change, Cartoon Network featured the first Powerpuff Girls pilots in its animation showcase program What a Cartoon! in 1995 and 1996. The series made its official debut as a Cartoon Cartoon on November 18, 1998.
Blossom (voiced by Cathy Cavadini) is the tactician and self-proclaimed leader of the Powerpuff Girls. Her personality ingredient is "everything nice", her signature color is pink, and she has long red hair with a red bow. She was named for having spoken freely and honestly to the Professor shortly after her creation as shown in the Powerpuff Girls Movie. She is often seen as the most level-headed, and composed member of the group and also strong and determined. Her unique power is freezing objects with her breath as seen in the episode "Ice Sore".
Bubbles (voiced by Tara Strong in the series and by Kath Soucie in the What a Cartoon! episodes) is the cute and sensitive one. Her personality ingredient is sugar, her signature color is blue, and she has short blonde hair in two pigtails. Bubbles is seen as kind and very sweet but she is also capable of extreme rage and can fight monsters just as well as her sisters can. Her best friend is a stuffed octopus doll she calls "Octi", and she also loves animals. She exhibits the ability to both understand multiple languages and communicate with various animals (squirrels, cats, monsters), and her unique power is emitting supersonic waves with her voice.
Buttercup (voiced by E. G. Daily) is the toughest of the three. Her personality ingredient is spice, her signature color is green, and she has short black hair in a flip. She is a tomboy who loves to get dirty, fights hard and plays rough; she does not plan and is all action. Buttercup is the only Powerpuff Girl without a unique super power (aside from being able to curl her tongue as shown in the episode "Nuthin' Special"). McCracken originally wanted to name the character "Bud" until a friend suggested the name Buttercup.
Professor Utonium (voiced by Tom Kane) is a brilliant scientist who works in his home in the suburbs of the City of Townsville.
The Mayor of Townsville (voiced by Tom Kenny in the series and by Jim Cummings in the What a Cartoon! episodes) is generally referred throughout only as "Mayor".
Ms. Sara Bellum (voiced by Jennifer Martin and by Julie Nathanson as a child) is The Mayor's very competent, pretty, statuesque, and apparently beautiful Secretary
Ms. Keane (voiced by Jennifer Hale, and by Kath Soucie in the What-a-Cartoon! episodes) is the kindergarten teacher of Pokey Oaks Kindergarten.
Narrator (voiced by Tom Kenny in the series and by Ernie Anderson in the What a Cartoon! episodes) is the enthusiastic but unseen narrator.
Talking Dog (voiced by Tom Kane in the series and by Paul Mercier in the What a Cartoon! episodes) is a small white dog
Mitchell "Mitch" Mitchelson (voiced by Tom Kenny): The bully at Pokey Oaks Kindergarten.
Mojo Jojo (voiced by Roger L. Jackson) is a mad scientist chimpanzee with great intelligence, who speaks in a Japanese accent poking fun at the poor dubbing of Speed Racer.
Him (voiced by Tom Kane) is a mysterious, supernatural, effeminate, immortal, androgynous, and demonic monster.
Fuzzy Lumkins (voiced by Jim Cummings) is a large, husky, furry pink bear/Bigfoot-like hillbilly monster.
Princess Morbucks (voiced by Jennifer Hale) is a spoiled, rich, and bratty little girl, whose partially unseen and mostly mute father allows her to finance various evil plots to destroy the Powerpuff Girls.
The Ganggreen Gang are a gang of five teenage hoodlums who are green-skinned and unhealthy looking.
The Amoeba Boys (voiced by Chuck McCann in the series and the What a Cartoon! episodes and by Lou Romano in Whoopass Stew) are a trio of amoebae who are the villains featured in McCracken's original short.
Sedusa (voiced by Jennifer Hale) is a young, beautiful mistress of disguise and seductress.
The Rowdyruff Boys are the male counterparts of the Powerpuff Girls created by Mojo Jojo using a mixture of "snips, snails, and a puppy dog tail" in the Townsville Prison in the episode called "The Rowdyruff Boys".
The Powerpunk Girls are the negative counterparts of the "Powerpuff Girls" from a parallel universe and are the complete opposites of their heroic counterparts.